ITCA 650
نویسندگان
چکیده
منابع مشابه
Randomized Trial of Continuous Subcutaneous Delivery of Exenatide by ITCA 650 Versus Twice-Daily Exenatide Injections in Metformin-Treated Type 2 Diabetes
OBJECTIVE To evaluate ITCA 650, a continuous subcutaneous miniature osmotic pump delivery system of exenatide versus twice-daily exenatide injections (Ex-BID) in subjects with type 2 diabetes. RESEARCH DESIGN AND METHODS We conducted a randomized, two-stage, 24-week, open-label, phase 2 study in type 2 diabetes inadequately controlled with metformin. Stage I: 155 subjects were randomized to 2...
متن کاملDmd049965 642..650
P-glycoprotein (P-gp) and CYP3A (cytochrome P450 3A, generally; Cyp3a, rodent enzyme) in the intestine can attenuate absorption of orally administered drugs. While some suggest that P-gp enhances intestinal metabolism by CYP3A/Cyp3a during absorption of a dual substrate, others suggest that P-gp reduces the metabolism in the intestine when substrates are at subsaturating concentrations. Hence, ...
متن کاملDmd055558 650..664
Recent analyses demonstrated that metabolites are unlikely to contribute significantly to clinical inhibition of cytochrome P450 (P450)– mediated drug metabolism, and that only ∼2% of this type of drug interaction could not be predicted from the parent drug alone. Due to generally increased polarity and decreased permeability, metabolites are less likely to interact with P450s, but their dispos...
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Ciprofloxacin, a quinolone with good intracellular penetration may possibly be used for treatment of melioidosis caused by Burkholderia pseudomallei, but problems with resistance may be encountered. Amino acid substitutions in gyrA/gyrB have given rise to fluoroquinolone resistance in various microorganisms. Using published primers for gyrA and gyrB, PCR was performed on 11 isolates of B. pseud...
متن کاملAn 8-b 650-MHz Folding ADC
An 8-b 650-MHz folding analog-to-digital converter (ADC) with analog error correction in the comparators is presented. With an input frequency of 150 MHz, 7.8 effective bits are obtained. The ADC is implemented in a 1-pm 13-GHz triple-level interconnect bipolar process, requiring 850 mW from a single -4.5-V supply. The die size is 4.2 mm’.
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ژورنال
عنوان ژورنال: Clinical Diabetes
سال: 2018
ISSN: 0891-8929,1945-4953
DOI: 10.2337/cd18-0039